Reactivities: | Human |
Presku: | AAP46853 |
Size: | 100ug |
Weight: | 37kDa |
Gene: | 25825 |
Format: | Lyophilized powder |
Target: | Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease and a frequent complication of Down syndrome. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein by 2 proteases, one of which is the protein encoded by this gene. This gene localizes to the 'Down critical region' of chromosome 21. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease. Three transcript variants encoding different isoforms have been described for this gene. |
Alternative names: | AEPLC; ALP56; ASP1; ASP21; BAE2; CDA13; CEAP1; DRAP |