Reactivities: | Mouse |
Presku: | AAP46850 |
Size: | 100ug |
Weight: | 56kDa |
Gene: | 23821 |
Format: | Lyophilized powder |
Target: | Bace1 is responsible for the proteolytic processing of the amyloid precursor protein (APP). Bace1 cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. |
Alternative names: | C76936 |