Ba, Xenopus/Amphibian, Antibody

Bcl-2 blocks cell death following a variety of stimuli and confers a death sparing effect to a certain hematopoietic cell lines following growth factor withdrawal. Bcl-2 appears to function in several subcellular locations yet lacks any known motifs that would confer insight into its mechanism of action. A more recently identified protein, designated as Ba, Xenopus/Amphibian, (Bcl-2 associated , Xenopus/Amphibian, protein, Bcl2-L-4, BCL2L4 associated , Xenopus/Amphibian, protein) has e, Xenopus/Amphibian,stensive amino acid homology with Bcl-2 and both homodimerizes and forms heterodimers with Bcl-2. Overe, Xenopus/Amphibian,pression of Ba, Xenopus/Amphibian, accelrates apoptotic death induced by cytokine deprivation in an IL-3 dependent cell line and Ba, Xenopus/Amphibian, also counters the death repressor activity of Bcl-2.