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ATXN3 (Human) cDNA (1ug)

ATXN3 (Human) cDNA (1ug)

Supplier: Aviva Systems Biology Incorporated
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The ORF of human ATXN3 is amplified by PCR using a high fidelity enzyme and sub-cloned into a Prokaryotic expression vector under the control of the tac promoter. The expression of the gene has been confirmed by Western blot using an anti-ATXN3 polyclonal antibody.
Presku: ANA10550
Size: 1ug
Gene: 4287
Target: Machado-Joseph disease, also known as spinocerebellar ataxia-3, is an autosomal dominant neurologic disorder. The protein encoded by this gene contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 13-36 to 68-79 is one cause of Machado-Joseph disease. There is a negative correlation between the age of onset and CAG repeat numbers. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
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