

Supplier:
Aviva Systems Biology IncorporatedATP2B4 (ATPase, Ca++ transporting, plasma membrane 4) Blocking Peptide (the middle region of protein) (100ug)
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SPECIFICATIONS
Size
100 ug
Format
Lyophilized powder
Presku
AAP44394
Target
ATP2B4 belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. ATP2B4 is the plasma membrane calcium ATPase isoform 4.The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 4. Alternatively spliced transcript variants encoding different isoforms have been identified.
Weight
129kDa
Gene Id
493
Alternative Names
ATP2B2; DKFZp686G08106; DKFZp686M088; MXRA1; PMCA4; PMCA4b; PMCA4x
Applications
ELISA
Hosts
Mouse
Reactivities
Rat
Applications
ELISA
Hosts
Mouse
Applications
FC
Hosts
Mouse
Reactivities
Hum
Applications
ELISA, WB
Hosts
Mouse
Reactivities
Hum
Applications
ELISA, IHC
Hosts
Mouse
Reactivities
Hum
Applications
ELISA
Hosts
Mouse
Reactivities
Hum
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