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Atf7ip (activating transcription factor 7 interacting protein ) Blocking Peptide (the middle region of Atf7ip)(100ug)

Atf7ip (activating transcription factor 7 interacting protein ) Blocking Peptide (the middle region of Atf7ip)(100ug)

This is a synthetic peptide designed for use in combination with anti-Atf7ip Antibody (ARP37246_P050), made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.

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SPECIFICATIONS

Size

100ug

Reactivities

Hum, Mouse

Format

Lyophilized powder

Presku

AAP37246

Target

Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Atf7ip can both act as an activator or a repressor depending on the context. It mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. Atf7ip is required to stimulate histone methyltransferase activity of SETDB1 and facilitate the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3). Atf7ip may have ATPase activity.

Weight

138kDa

Gene Id

54343

Alternative Names

2610204M12Rik; AM; Mcaf1

SUPPLIER INFO

Aviva Systems Biology Incorporated

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