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Atf7ip (activating transcription factor 7 interacting protein ) Blocking Peptide (the middle region of Atf7ip)(100ug)

Atf7ip (activating transcription factor 7 interacting protein ) Blocking Peptide (the middle region of Atf7ip)(100ug)

Supplier: Aviva Systems Biology Incorporated
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This is a synthetic peptide designed for use in combination with anti-Atf7ip Antibody (ARP37246_P050), made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Reactivities: Human, Mouse
Presku: AAP37246
Size: 100ug
Weight: 138kDa
Gene: 54343
Format: Lyophilized powder
Target: Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Atf7ip can both act as an activator or a repressor depending on the context. It mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. Atf7ip is required to stimulate histone methyltransferase activity of SETDB1 and facilitate the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3). Atf7ip may have ATPase activity.
Alternative names: 2610204M12Rik; AM; Mcaf1
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