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Arhgef4 (Rho guanine nucleotide exchange factor (GEF) 4 ) Blocking Peptide (the N terminal of Arhgef4)(100ug)

Arhgef4 (Rho guanine nucleotide exchange factor (GEF) 4 ) Blocking Peptide (the N terminal of Arhgef4)(100ug)

This is a synthetic peptide designed for use in combination with anti-Arhgef4 Antibody (ARP59254_P050), made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.

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SPECIFICATIONS

Size

100ug

Reactivities

Hum, Mouse

Format

Lyophilized powder

Presku

AAP59254

Target

Arhgef4 acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion By similarity. It is required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Arhgef4 is involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.

Weight

57kDa

Gene Id

226970

Alternative Names

9330140K16Rik; Asef; ENSMUSG00000070955

SUPPLIER INFO

Aviva Systems Biology Incorporated

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