AQP2 (Ser269) Antibody

Aquaporin-2 (AQP-2) forms a water specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. It is e, Xenopus/Amphibian,pressed in the renal collecting tubules. Defects in AQP-2 are a cause of autosomal recessive nephrogenic diabetes insipidus (ANDI), also known as diabetes insipidus nephrogenic type 2. It is characterized by e, Xenopus/Amphibian,cessive water drinking (polydypsia) and urine e, Xenopus/Amphibian,cretion (polyuria). AQP-2 belongs to the MIP/aquaporin (TC1.A.8) family. Serine-269 has been identified as a vasopressin-mediated phosphorylation site on AQP2 and as such has shown to potentiate plasma membrane retention of AQP2.