APC anti-mouse LAP (TGF-beta1)

Transforming growth factor beta (TGF-beta) is a cytokine that has critical functions in the immune response by regulating Treg and Th17 cells. TGF-beta is first synthesized as pro-TGF-beta and then it is cleaved by furin proprotein convertase in the Golgi apparatus to produce the dimeric propeptides called latency-associate peptide (LAP) that non-covalently associates with the dimeric mature TGF-beta to prevent its activity. This complex can further associate with latent-TGF-beta-binding protein (LTBP) to produce a large latent form for deposition onto the extracellular matrix. The latent-TGF-beta can be expressed on the membrane of activated Treg cells, immature dendritic cells, megakaryocytes, and platelets.

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SPECIFICATIONS

Catalog Number

141405

Size

25 microg

Applications

FC

Hosts

Mouse

Reactivities

Mouse

Clone

TW7-16B4

Antigen

Mouse Tgfb1-transduced P3U1 cells

Gene Id

21803

Isotype

Mouse IgG1, kappa

Clonality

Monoclonal

Dilutions

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ?0.5 microg per million cells in 100 microl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Storage Temp

4 C

Concentration

0.2 mg/ml

Shipping Temp

Ambient RT

Storage Buffer

The antibody solution should be stored undiluted at 4C and protected from prolonged exposure to light. Do not freeze.

Alternative Names

TGFB, TGFB1, DPD1, Latency Associated Peptide (LAP), TGF-beta1, TGF-beta

Regulatory Status

RUO