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APC anti-human/mouse/rat CD278 (ICOS)

APC anti-human/mouse/rat CD278 (ICOS)

Cat no: 313509

Supplier: BioLegend
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ICOS, also known as inducible costimulatory molecule and H4, is a 47-57 kD protein. This protein is homologous to the CD28/CTLA-4 proteins. ICOS is expressed on activated T cells and a subset of thymocytes. It is able to costimulate T cells proliferation. In addition, ICOS is involved in humoral immune responses (B cell germinal center formation). The ICOS ligand is B7h/B7RP-1 or B7-H2. ICOS stimulation has been shown to potentiate TCR-mediated IL-4 and IL-10 production and has been proposed to play a role in Th2 cell development.
Catalogue number: 313509
Reactivities: Human, Mouse, Rat
Hosts: Hamster
Applications: Flow Cytometry
Size: 25 microg
Clone: C398.4A
Gene: 100048841,29851,64545
Dilutions: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ? 1.0 microg per 106 cells in 100 microl volume. It is recommended that reagents be titrated for optimal performance in the particular application.
Storage buffer: The antibody solution should be stored undiluted at 4C and protected from prolonged exposure to light. Do not freeze.
Concentration: 0.2 mg/ml
Antigen: Mouse T cell clone D10.G4.1
Isotype: Armenian Hamster IgG
Clonality: Monoclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: 4 C
Alternative names: Inducible COStimulatory molecule, H4
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