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APBA2BP (Human) cDNA (1ug)

APBA2BP (Human) cDNA (1ug)

The ORF of human APBA2BP is amplified by PCR using a high fidelity enzyme and sub-cloned into a Prokaryotic expression vector under the control of the tac promoter. The expression of the gene has been confirmed by Western blot using an anti-APBA2BP polyclonal antibody.

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SPECIFICATIONS

Size

1ug

Presku

ANA11195

Target

The protein encoded by this gene interacts with the amino-terminal domain of the neuron-specific X11-like protein (X11L), inhibits the association of X11L with amyloid precursor protein through a non-competitive mechanism, and abolishes the suppression of beta-amyloid production by X11L. This protein, together with X11L, may play an important role in the regulatory system of amyloid precursor protein metabolism and beta-amyloid generation. The protein is phosphorylated by NIMA-related expressed kinase 2, and localizes to the Golgi apparatus. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene Id

63941

SUPPLIER INFO

Aviva Systems Biology Incorporated

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