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Anti-Thyroid Hormone Receptor, beta -Isotype

Anti-Thyroid Hormone Receptor, beta -Isotype


Supplier: Aviva Systems Biology Incorporated
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Specific for the ~55k TR- beta protein. Prepared from mouse ascites by ammonium sulfate precipitation followed by affinity purification on a protein G column.
Reactivities: Human
Hosts: Mouse
Applications: Western Blot
Presku: OAPC00014
Size: 100 ul
Weight: ~55kDa
Clone: 2386
Gene: 7068
Format: Affinity purified, monoclonal antibody
Target: Thyroid hormones are essential for development of the central nervous system and deficits in these hormones during development affects such cognitive functions as learning and memory (Ambrogini et al., 2005; Chan and Kilby, 2000). Thyroid hormones exert their physiological role mainly through binding to specific nuclear receptors including the predominant isoforms of thyroid hormone receptors TR alpha 1, TR alpha 2, TR beta 1 and TR beta 2. TR alpha 1, TR beta 1 and TR beta 2 bind T3 with high affinity and also bind to thyroid hormone response elements (TREs) on chromatin to regulate the transcriptional processes in several target tissues, including adult rat brain (Constantinou et al., 2005).
Isotype: IgG1