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Anti-Thyroid Hormone Receptor, alpha <sub>1</sub>/ alpha <sub>2</sub>-Isotype

Anti-Thyroid Hormone Receptor, alpha <sub>1</sub>/ alpha <sub>2</sub>-Isotype

Supplier: Aviva Systems Biology Incorporated
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Specific for the ~50k TR- alpha 1 and the ~58k TR- alpha 2 protein. Prepared from mouse ascites by ammonium sulfate precipitation followed by affinity purification on a protein G column.
Reactivities: Human, Mouse, Rat, Canine
Hosts: Mouse
Applications: Western Blot
Presku: OAPC00012
Size: 100 ul
Weight: ~50kDa Alpha1 & ~58kDa Alpha3
Clone: 1718
Gene: 7067
Format: Affinity purified, monoclonal antibody
Target: Thyroid hormones are essential for development of the central nervous system and deficits in these hormones during development affects such cognitive functions as learning and memory (Ambrogini et al., 2005; Chan and Kilby, 2000). Thyroid hormones exert their physiological role mainly through binding to specific nuclear receptors including the predominant isoforms of thyroid hormone receptors TR alpha 1, TR alpha 2, TR beta 1 and TR beta 2. TR alpha 1, TR beta 1 and TR beta 2 bind T3 with high affinity and also bind to thyroid hormone response elements (TREs) on chromatin to regulate the transcriptional processes in several target tissues, including adult rat brain (Constantinou et al., 2005).
Isotype: IgG2A
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