Supplier:
Aviva Systems Biology IncorporatedAnti-Thyroid Hormone Receptor, alpha <sub>1</sub>/ alpha <sub>2</sub>-Isotype
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SPECIFICATIONS
Size
100 ul
Applications
WB
Hosts
Mouse
Reactivities
Hum, Mouse, Rat, Can
Clone
1718
Format
Affinity purified, monoclonal antibody
Presku
OAPC00012
Target
Thyroid hormones are essential for development of the central nervous system and deficits in these hormones during development affects such cognitive functions as learning and memory (Ambrogini et al., 2005; Chan and Kilby, 2000). Thyroid hormones exert their physiological role mainly through binding to specific nuclear receptors including the predominant isoforms of thyroid hormone receptors TR alpha 1, TR alpha 2, TR beta 1 and TR beta 2. TR alpha 1, TR beta 1 and TR beta 2 bind T3 with high affinity and also bind to thyroid hormone response elements (TREs) on chromatin to regulate the transcriptional processes in several target tissues, including adult rat brain (Constantinou et al., 2005).
Weight
~50kDa Alpha1 & ~58kDa Alpha3
Gene Id
7067
Isotype
IgG<sup>2A</sup>
SUPPLIER INFO
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