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Anti-Syntaxin 1A

Anti-Syntaxin 1A

Supplier: Aviva Systems Biology Incorporated
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The antibody is specific for the ~ 36 kDa syntaxin protein in Western blots of rat brain lysate. The antibody has also been used for immunohistochemistry on formalin fixed, vibratome sections. Does not work on paraffin sections. Protein G purified culture supernatant.
Reactivities: Human, Rat, Porcine
Hosts: Mouse
Applications: Immunohistochemistry, Western Blot
Presku: OAPC00068
Size: 100 ul
Weight: ~36kDa
Clone: SP8
Gene: 6804
Format: Purified mouse monoclonal antibody
Target: Syntaxins are a family of proteins involved in the docking of synaptic vesicles with the plasma membrane. Syntaxin, along with synaptobrevin and SNAP-25, forms the SNARE complex which mediates synaptic vesicle fusion and exocytosis. Binding of Munc18-1 to the N-terminus of syntaxin 1 has been demonstrated to be essential for exocytic membrane fusion (Khvotchev et al., 2007). Decreased levels of phosphorylated syntaxin 1 in the prefrontal cortex have recently been correlated with schizophrenia (Castillo et al., 2010).
Isotype: IgG1
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