Supplier:
Aviva Systems Biology IncorporatedAnti-Synaptojanin I
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SPECIFICATIONS
Size
100 ul
Applications
IHC, WB
Hosts
Mouse
Reactivities
Rat
Format
Affinity purified monoclonal antibody
Presku
OAPC00065
Target
Synaptojanin is a phosphatidylinositol phosphatase involved in clathrin-mediated endocytosis of synaptic vesicles. Synaptojanin 1 has two alternatively spliced isoforms; one that is ~ 145 kDA and is exclusively expressed in neurons, and the other ~ 170 kDa which is expressed in non-neuronal, peripheral tissues (Ramjaun AR & McPherson PS, 1996). The gene which encodes Synaptojanin 1, SYNJ1, has been mapped to chromosome 21 thus making it a candidate for involvement in Down's syndrome (DS). It has recently been demonstrated that Ts65Dn mice (the most commonly used model of DS) have altered phosphatidylinositol-4,5-bisphosphate metabolism. This defect is rescued by restoring SYNJ1 to disomy in the Ts65Dn mice (Voronov SV et al., 2008).
Weight
~145kDa
Gene Id
85238
Isotype
IgG
SUPPLIER INFO
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