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Anti-Synaptojanin I

Anti-Synaptojanin I

Supplier: Aviva Systems Biology Incorporated
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Specific for the ~145k synaptojanin I protein in Western blots of rat brain extracts. Immunolabeling blocked by preadsorption of antibody with the protein used to generate the antibody. Protein G purified culture supernatant.
Reactivities: Rat
Hosts: Mouse
Applications: Immunohistochemistry, Western Blot
Presku: OAPC00065
Size: 100 ul
Weight: ~145kDa
Gene: 85238
Format: Affinity purified monoclonal antibody
Target: Synaptojanin is a phosphatidylinositol phosphatase involved in clathrin-mediated endocytosis of synaptic vesicles. Synaptojanin 1 has two alternatively spliced isoforms; one that is ~ 145 kDA and is exclusively expressed in neurons, and the other ~ 170 kDa which is expressed in non-neuronal, peripheral tissues (Ramjaun AR & McPherson PS, 1996). The gene which encodes Synaptojanin 1, SYNJ1, has been mapped to chromosome 21 thus making it a candidate for involvement in Down's syndrome (DS). It has recently been demonstrated that Ts65Dn mice (the most commonly used model of DS) have altered phosphatidylinositol-4,5-bisphosphate metabolism. This defect is rescued by restoring SYNJ1 to disomy in the Ts65Dn mice (Voronov SV et al., 2008).
Isotype: IgG
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