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Anti-Synaptobrevin (VAMP)

Anti-Synaptobrevin (VAMP)

Supplier: Aviva Systems Biology Incorporated
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The antibody is specific for the ~16kDa synaptobrevin protein in Western blots of rat brain lysate. The antibody has also been demonstrated to work in immunohistochemistry on formalin fixed, vibratome sections, but does not work on paraffin sections. Purified culture supernatant.
Reactivities: Human, Mouse, Rat, Bovine, Porcine, Rabbit
Hosts: Mouse
Applications: Immunohistochemistry, Western Blot
Presku: OAPC00064
Size: 100 ul
Weight: ~16kDa
Clone: SP10
Gene: 6843
Format: Purified mouse monoclonal antibody
Target: Synaptobrevin (aka VAMP) is an integral membrane protein of synaptic vesicles that plays a major role in the formation of larger SNARE complexes, along with SNAP-25 and syntaxin. Synaptobrevin has been shown to be essential for two fast synapse-specific membrane trafficking processes: fast exocytosis for neurotransmitter release and fast endocytosis that mediates rapid recycling of synaptic vesicles (Deak et al., 2004). Decreased levels of synaptobrevin in human hippocampus and cortex have been correlated with cognitive defects in Alzheimer's disease (Sze et al., 2000).
Isotype: IgM
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