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anti-SUMO2/3 antibody, rat monoclonal (3H12)

Cat no: 70-657

anti-SUMO2/3 antibody, rat monoclonal (3H12)

SUMO (Small Ubiquitin-like Modifier) proteins are a family of small proteins that are covalently attached to and detached from other proteins in cells to modify their function. Unlike ubiquitination, which targets proteins for degradation, SUMO modification plays a critical role in a number of cellular functions including nucleocytoplasmic transport gene expression cell cycle and formation of subnuclear structures such as promyelocytic leukemia (PML) bodies.There are three confirmed SUMO isoforms in human; SUMO1, SUMO2, and SUMO3. SUMO2 and SUMO3 show a high degree of similarity to each other and are distinct from SUMO1. Individual SUMO family members are all targeted to different proteins with diverse biological functions. SUMO2/3 forms poly-SUMO chains is conjugated to topoisomerase II and APP and regulates chromosomal segregation and cellular responses to environmental stress.This antibody recognizes both SUMO2 and SUMO3, but not SUMO1. This antibody was produced from the hybridoma cultured in serum-free medium and purified under mild conditions by propriety chromatography processes.

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SPECIFICATIONS

Catalog Number

70-657

Size

100 ug

Applications

ELISA, ICC, IF, IHC, WB

Hosts

Rat

Reactivities

Hum, Mouse, Rat, Ham

Gene Id

P61956, P55854

Clonality

Monoclonal

Storage Temp

- 20 degree C

Shipping Temp

blue ice

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