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Anti-Retinoid X Receptor, gamma -Isotype

Anti-Retinoid X Receptor, gamma -Isotype

Supplier: Aviva Systems Biology Incorporated
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Specific for the ~48k RXR- gamma isotype. Prepared from mouse ascites by ammonium sulfate precipitation followed by affinity purification on a protein G column.
Reactivities: Human, Mouse, Rat, Bovine
Hosts: Mouse
Applications: Western Blot
Presku: OAPC00016
Size: 100 ul
Weight: ~48kDa
Clone: 1373
Gene: 6258
Format: Affinity purified, monoclonal antibody
Target: Retinoic acid (RA; active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells (Joshi et al., 2005). The Retinoid X Receptors (RXRs) family (RXR alpha, beta and gamma) preferentially bind 9-cis-RA and regulate gene transcription by forming heterodimers with a second family of RA receptors. RAs have been suggested to potentially play a therapeutic role in cervical cancer (Abu et al., 2005). RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors (Lane and Bailey, 2005).
Isotype: IgG1
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