RagA (313 aa 36.6 kDa) is the human homologue of Gtr1 identified in yeast and classified as the Ras-like small G protein family. In cytoplasm GTP-bound RagA usually forms a heterodimer with RagD interacts with Nop132 to be transported to the nucleous. GTP of RagA is hydrolyzed to GDP by RCC guanine nucleotide exchange factor for RanGTPase bound to chromatin. RagA-RCC signal pathway has a crucial role in cell growth and differentiation. RagA is also well known to be involved in mTOR signaling via binding with raptor a component of mTORC1 complex in an amino acid sensitive manner. Applications: WB