Prion protein PrP is a membrane glycosylphosphatidylinositol(GPI) anchored glycoprotein highly expressed in neurons and glial cells, as well as immune and reproductive cells. Mutations, mostly in the octapeptide repeat regions, have been associated with neurodegenerative diseases such as Creutzfeldt Jakob disease, fatal familial insomnia, Gerstmann Straussler disease, Huntington disease like 1, and kuru. The infectious isoform of PrPC, known as PrPSc, is able to induce a conformational change in normal PrPC proteins to convert them into the infectious isoform.