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Anti-Phospho-Tyr<sup>317</sup> EphrinB

Anti-Phospho-Tyr<sup>317</sup> EphrinB

Specific for the ~46k EphrinB protein phosphorylated at Tyr317. The immunolabeling of the EphrinB band is blocked by treatment with lambda -phosphatase. Prepared from rabbit serum by affinity purification via sequential chromatography on phospho- and dephosphopeptide affinity columns.

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SPECIFICATIONS

Size

100 ul

Applications

WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat, Bov, Ch/Bird, ZF/Fish

Format

Affinity purified, polyclonal antibody

Presku

OAPC00156

Target

EphrinB proteins are thought to play key roles in cellular functions as diverse as neuronal migration and blood vessel development (Flanagan and Vanderhaeghen, 1998; Dufour et al., 2003; Oike et al., 2002). EphrinB molecules expressed at the membrane surface bind to the EphB family receptors on target cells during cell-to cell contact. This interaction leads to cell signaling in the target cell but also generates a reverse signal in the cell expressing EphrinB on its surface. This reverse signaling event is thought to be critical for vessel maturation and neuronal development. Importantly, tyrosine phosphorylation of EphrinB is thought to be a critical component of this reverse signaling event (Palmer et al., 2002). Recent work suggests that phosphorylation of a specific EphrinB residue (Tyr298) plays a key role in EphrinB signaling (Kalo, et al., 2001).

Weight

~46kDa

Gene Id

396513

SUPPLIER INFO

Aviva Systems Biology Incorporated

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