Supplier:
Aviva Systems Biology IncorporatedAnti-Phospho-Tyr<sup>1336</sup> NMDA Receptor NR2B Subunit
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SPECIFICATIONS
Size
100 ul
Applications
IHC, WB
Hosts
Rabbit
Reactivities
Hum, Mouse, Rat
Format
Affinity purified, polyclonal antibody
Presku
OAPC00182
Target
The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer's, epilepsy and ischemic neuronal cell death (Grosshans et al., 2002; Wenthold et al., 2003; Carroll and Zukin, 2002). The rat NMDAR1 (NR1) was the first subunit of the NMDAR to be cloned. The NR1 protein can form NMDA activated channels when expressed in Xenopus oocytes but the currents in such channels are much smaller than those seen in situ. Channels with more physiological characteristics are produced when the NR1 subunit is combined with one or more of the NMDAR2 (NR2 A-D) subunits (Ishii et al., 1993). Phosphorylation of Tyr1336 is thought to potentiate NMDA receptor-dependent influx of calcium (Takasu et al., 2002) and ischemia may also increase the phosphorylation of this site (Takagi et al., 2003).
Weight
~180kDa
Gene Id
24410
SUPPLIER INFO
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