Supplier:
Aviva Systems Biology IncorporatedAnti-Phospho-Thr<sup>402</sup> PAK-1,2,3
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SPECIFICATIONS
Size
100 ul
Applications
WB
Hosts
Rabbit
Reactivities
Hum, Mouse, Rat, Bov, Can
Format
Affinity purified, polyclonal antibody
Presku
OAPC00214
Target
In mammals, there are several identified isoforms of p21-activated protein kinases or PAKs: alpha -PAK (also known as PAK-1) and beta -PAK (also known as PAK-3) are mostly brain-specific, while gamma -PAK (also known as PAK-2) is expressed ubiquitously (Jakobi et al., 2003). Mutations of the gene coding for PAK-3 are associated with X-linked mental retardation and recent work indicates that PAK-3 is a key regulator of synapse formation and plasticity in the hippocampus (Boda et al., 2004). PAK-3 is thought to play a key role in regulation of cell shape and motility as well as cell death (Jakobi et al., 2003; Walter et al., 1998). Autophosphorylation of Thr402 in the protein has been found to be essential for activation of PAK (Jakobi et al., 2000).
Weight
~68kDa - ~70kDa
Gene Id
29431
SUPPLIER INFO
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