Supplier:
Aviva Systems Biology IncorporatedAnti-Phospho-Thr<sup>305</sup> CaM Kinase II
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SPECIFICATIONS
Size
100 ul
Applications
WB
Hosts
Rabbit
Reactivities
Hum, Mouse, Rat, Bov, Can, Ch/Bird, ZF/Fish
Format
Serum
Presku
OAPC00146
Target
Ca2+/Calmodulin-Dependent Protein Kinase II (CaM Kinase II) is amulti-functional calcium and calmodulin-dependent protein kinase that mediates cellularresponses to a wide variety of intercellular signals (Kennedy, 1998; Schulman and Hanson,1993). CaM Kinase II has been shown to regulate diverse cellular functions including synapticplasticity, neurotransmitter synthesis and release, gene expression, ion channel function,carbohydrate metabolism, cytoskeletal function, and Ca2+-homeostasis (Gleason et al., 2003;Soderling, 2000; Hudmon and Schulman, 2002). Phosphorylation of Thr286 on the kinaseproduces an autonomously active form of CaM Kinase II (Meng et al., 2003; Picciotto et al.,1993). Autophosphorylation of Thr305 inhibits the activity of CaM Kinase II. Phosphorylation atthis site appears to reduce the association of CaM Kinase II with the PSD and reduce LTP andlearning (Elgersma et al., 2002).
Weight
~50kDa Alpha & ~60kDa Beta
Gene Id
25400
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