Supplier:
Aviva Systems Biology IncorporatedAnti-Phospho-Ser<sup>892</sup> GABA<sub>B</sub> Receptor, R2-Subunit
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SPECIFICATIONS
Size
100 ul
Applications
IF, WB
Hosts
Rabbit
Reactivities
Hum, Mouse, Rat, Bov, Can, Ch/Bird, ZF/Fish
Format
Affinity purified, polyclonal antibody
Presku
OAPC00164
Target
Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors the GABAA and the GABAB subtype of receptors. GABAB receptors are heterodimeric G protein-coupled receptors that mediate slow synaptic inhibition in the central nervous system. Moss and colleagues (Couve, et al., 2002) recently demonstrated that the functional coupling of GABAB R1/GABAB R2 receptors to inwardly rectifying K+ channels rapidly desensitizes. This effect is alleviated after direct phosphorylation of a single serine residue (Ser892) in the cyto-plasmic tail of GABAB R2 by cyclic AMP (cAMP)-dependent protein kinase (PKA). In addition to it's postsynaptic effects GABAB receptors localized to the presynaptic region have been reported to restrict the availability of synaptic vesicles for release (Sakaba and Neher, 2003).
Weight
~110kDa
Gene Id
83633
SUPPLIER INFO
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