Supplier:
Aviva Systems Biology IncorporatedAnti-Phospho-Ser<sup>482,486,490</sup> Polo-Like Kinase Kinase
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SPECIFICATIONS
Size
100 ul
Applications
WB
Hosts
Rabbit
Reactivities
Hum, Mouse, Rat, ZF/Fish
Format
Affinity Purified, Polyclonal antibody
Presku
OAPC00219
Target
Considerable evidence indicates that a polo-like kinase (PLK) plays an important role in cell cycle regulation. PLK is also required for bipolar spindle formation, activation of the anaphase-promoting complex/cyclosome, and cytokinesis. Recent work led to the identification of a PLKK that is thought to be responsible for activation of PLK. Recent work (Erikson, et al., 2004) has shown that PLKK is in turn activated by phosphorylation at three sites (Ser482, Ser486 and Ser490). Thus activation of PLK is thought to involve a kinase cascade involving the phosphorylation of Ser482,486,490 in PLKK.
Weight
~120kDa
Gene Id
380481
SUPPLIER INFO
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