Supplier:
Aviva Systems Biology IncorporatedAnti-Phospho-Ser<sup>41</sup> Gap-43
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SPECIFICATIONS
Size
100 ul
Applications
WB
Hosts
Rabbit
Reactivities
Hum, Mouse, Rat, Bov, Can, Ch/Bird, ZF/Fish
Format
Affinity purified, polyclonal antibody
Presku
OAPC00166
Target
Gap-43 is thought to have an important role in development and plasticity because it is expressed at high levels in neuronal growth cones during development and during axonal regeneration (Benowitz and Routtenberg, 1997). There is also evidence from knockout animals that Gap-43 serves to amplify pathfinding signals from the growth cone (Strittmatter et al., 1995). Gap-43 is thought to mediate at least some of these effects via interaction with actin. Importantly, phosphorylation at Ser41 by protein kinase C modulates the interaction of Gap-43 with actin (He et al., 1997) and may also affect neurotransmitter release during forms of plasticity like LTP (Hulo et al., 2002).
Weight
~50kDa
Gene Id
29423
SUPPLIER INFO
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