Supplier:
Aviva Systems Biology IncorporatedAnti-Phospho-Ser<sup>378</sup> Parkin
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SPECIFICATIONS
Size
100 ul
Applications
WB
Hosts
Rabbit
Reactivities
Hum
Format
Affinity purified, polyclonal antibody
Presku
OAPC00218
Target
Parkin is an E3 ligase in the ubiquitin-proteasome system. Hereditary Parkinson's disease is most commonly caused by mutations in the parkin gene and is characterized by the progressive loss of dopaminergic neurons and the presence of Lewy bodies in the substania nigra (Jenner et al.,1992). Recent evidence suggests that phosphorylation of parkin at Ser378 may have an important regulatory role on its E3 ubiquitin ligase activity (Yamamoto et al., 2005).
Weight
~52kDa
Gene Id
5071
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