Anti-Phospho-Ser327 GABAA Receptor, gamma 2 subunit

Specific for ~45k GABAA receptor gamma 2 subunit phosphorylated at Ser327. Immunolabeling of the GABAA band is completely blocked by lambda -phosphatase treatment. Prepared from rabbit serum by affinity purification via sequential chromatography on phospho- and dephospho-peptide affinity columns.

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SPECIFICATIONS

Size

100 ul

Applications

WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat, Bov, Can, Ch/Bird

Format

Affinity purified, polyclonal antibody

Presku

OAPC00161

Target

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors: the GABAA and the GABAB subtype of receptors. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and sub-stance abuse. The GABAA-R is a multimeric subunit complex. To date six alpha s, four beta s and four gamma s, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990; Whiting et al., 1999; Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for alpha - and beta -subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a gamma -subunit is required for benzodiazepine modulation. It has recently been suggested that PKC epsilon regulates the sensitivity of GABAA alpha 1 beta 2 gamma 2 receptors to ethanol and benzodiazepines through phosphorylation of serine 327 in the large intracellular loop of gamma 2 (Qi et al., 2007)

Weight

~45kDa

Gene Id

29709