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Anti-Phospho-Ser<sup>294</sup> Progesterone Receptor

Anti-Phospho-Ser<sup>294</sup> Progesterone Receptor

Supplier: Aviva Systems Biology Incorporated
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Specific for the ~90k PR-A isoform and the ~120k PR-B isoform phosphorylated at Ser294. Immunolabeling is blocked by the phosphopeptide used as the antigen but not by the corresponding dephosphopeptide. Prepared by affinity purification using a protein G column.
Reactivities: Human
Hosts: Mouse
Applications: Immunohistochemistry, Western Blot
Presku: OAPC00223
Size: 100 ul
Weight: ~90-120 kDa
Clone: 608
Gene: 5241
Format: Affinity purified, monoclonal antibody
Target: There is accumulating evidence to suggest that progesterone plays an essential role in the regulation of growth and differentiation of mammary glands and thus may play a key role in breast cancer (Edwards, 2005). The biological response to progesterone is mediated by two distinct forms of the human progesterone receptor (PR-A and PR-B forms). In most cell contexts, the B form functions as a transcriptional activator, whereas the A form functions as a transcriptional inhibitor of steroid hormones (Attia et al., 2000; Lin et al., 2003). Recently it has been demonstrated that there is differential hormone dependent regulation of the phosphorylation of the A and B forms of the receptor (Clemm et al., 2000). Treatment of T47D breast cancer cells with progestin agonist increases the phosphorylation of Ser190 and Ser294 with different kinetics. These phosphorylation events may differentially affect the transcriptional activity of the receptor.
Isotype: IgG1
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