Supplier:
Aviva Systems Biology IncorporatedAnti-Phospho-Ser<sup>264</sup> Aquaporin 2
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SPECIFICATIONS
Size
100 ul
Applications
IHC, WB
Hosts
Rabbit
Reactivities
Hum, Mouse, Rat, Bov, Can, Ch/Bird
Format
Affinity purified polyclonal antibody
Presku
OAPC00159
Target
Aquaporin 2 (AQP2) is a hormonally regulated water channel located in the renal collecting duct. Mutations in the AQP2 gene cause hereditary nephrogenic diabetes insipidus in humans (Iolascon et al.,2007). A vasopressin induced cAMP increase results in the phosphorylation of AQP2 at serine-256 and its translocation from the intracellular vesicles to the apical membrane of principal cells (van Balkom et al., 2002). Recently, serine-264 has been identified as a novel phosphorylation site on AQP2 and shown to be regulated by vasopressin thus implicating this site as important in AQP2 trafficking and subcellular distribution (Fenton RA et al., 2008).
Weight
~29/37kDa
Gene Id
25386
SUPPLIER INFO
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