Supplier:
Aviva Systems Biology IncorporatedAnti-Phospho-Ser<sup>190</sup> Progesterone Receptor
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SPECIFICATIONS
Size
100 ul
Applications
IHC, WB
Hosts
Mouse
Reactivities
Hum
Clone
1154
Format
Affinity purified, monoclonal antibody
Presku
OAPC00222
Target
There is accumulating evidence to suggest that progesterone plays an essential role in the regulation of growth and differentiation of mammary glands and thus may play a key role in breast cancer (Edwards, 2005). The biological response to progesterone is mediated by two distinct forms of the human progesterone receptor (PR-A and PR-B forms). In most cell contexts, the B form functions as a transcriptional activator, whereas the A form functions as a transcriptional inhibitor of steroid hormones (Attia et al., 2000; Lin et al., 2003). Recently it has been demonstrated that there is differential hormone dependent regulation of the phosphorylation of the A and B forms of the receptor (Clemm et al., 2000). Treatment of T47D breast cancer cells with progestin agonist increases the phosphorylation of Ser190 and Ser294 with different kinetics. These phosphorylation events may differentially affect the transcriptional activity of the receptor.
Weight
~90-120 kDa
Gene Id
5241
Isotype
IgG<sup>1</sup>
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