Anti-PHLDA3 antibody, monoclonal (4B6)

PHLDA3 (Pleckstrin homology-like domain family A member 3) is a small PH (Pleckstrin homology) domain-only protein (127 a.a. in human) that is highly conserved in vertebrates. Recently PHLDA3 was found to be a p53-regulated repressor of Akt (ref 2), hence it is speculated as a tumor suppressor. PHLDA3 also inhibits anchorage-independent cell growth. PHLDA3 gene is frequently lost in human lung endocrine tumors. The antibody was produced from the hybridoma cultured in serum-free medium and purified under mild conditions by propriety chromatography processes. This antibody has only been tested in Western blotting applications.