Supplier:
Aviva Systems Biology IncorporatedAnti-Norepinephrine Transporter
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SPECIFICATIONS
Size
100 ul
Applications
WB
Hosts
Mouse
Reactivities
Mouse, Rat
Format
Affinity purified, monoclonal antibody
Presku
OAPC00022
Target
Norepinephrine Transporter [NET] (or noradrenaline transporter (NAT)) is a monoamine transporter that transports the neurotransmitter noradrenaline from the synapse back to its vesicles for storage until later use. It also appears to transport the neurotransmitter dopamine in the same way, but to a lesser degree. Studies have shown a decrease in NET levels in the locus coeruleus in patients diagnosed with major depression (Klimek et al., 1997). Cocaine, amphetamines and many therapeutic antidepressants, such as the SNRIs (Serotonin-norepinephrine reuptake inhibitors) and the tricyclic antidepressants (TCAs) act to raise noradrenaline. Furthermore, deficits in the NET gene have been associated with ADHD (Kim et al., 2006).
Weight
~55kDa
Gene Id
Mm.57040
Isotype
IgG<sup>2b</sup>
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