Anti-NMDA Receptor, NR1 Subunit, C2' Splice Variant Insert

Specific for the ~120k NR1 subunit of the NMDA receptor containing the C2' splice variant insert. Does not recognize the NR1 subunits of the NMDA receptor that do not contain the C2' insert. Prepared from rabbit serum by affinity purification using a column to which the peptide immunogen was coupled.

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SPECIFICATIONS

Size

25 ug

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat, Bov

Format

Affinity purified, polyclonal antibody

Presku

OAPC00042

Target

The NMDA receptor (NMDAR) plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer's, epilepsy and ischemic neuronal cell death (Grosshans et al., 2002; Wenthold et al., 2003; Carroll and Zukin, 2002). Increased membrane surface expression of the NMDAR, NR1-Subunit has been associated with synaptic plasticity (Grosshans et al., 2002). There are a number of different splice variants of the NR1-Subunit (Foldes et al., 1994; Zukin and Bennett, 1995). Differential splicing of three exons in the NR1-Subunit generates up to eight NR1-Subunit splice variants and 7 of these have been identified in cDNA libraries. These exons encode a 21 amino acid N-terminal domain (N1) and adjacent sequences in the C-terminus (C1 and C2). Splicing out the C2 cassette eliminates the first stop codon and produces a new reading frame that generates a new sequence of 22 amino acids (C2'). Considerable attention has been focused on the distribution and expression of these splice variants that may affect the functional properties and regulation of the NMDAR.

Weight

~120kDa

Gene Id

24408