Supplier:
Aviva Systems Biology IncorporatedAnti-Metabotropic Glutamate Receptor 2/3
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SPECIFICATIONS
Size
100 ul
Applications
IHC, WB
Hosts
Rabbit
Reactivities
Hum, Mouse, Rat, Bov, Can, ZF/Fish
Format
Affinity purified, polyclonal antibody
Presku
OAPC00078
Target
The metabotropic glutamate receptors (mGluRs) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system. They are implicated in many forms of neural plasticity as well as learning and memory and drug abuse (Bhattacharya et al., 2004; Francesconi et al., 2004; Wilson and Nicoll, 2001). Group I metabotropic glutamate receptors (consisting of mGluR1 and mGluR5) are G-protein-coupled neurotransmitter receptors that are localized in the perisynaptic region of the postsynaptic membrane. When activated, Group I mGluRs lead to stimulation of phospholipase and activation of Protein Kinase C. In contrast, activation of Group II metabotropic receptors (mGluR2 and mGluR3) leads to inhibition of adenylate cyclase. The mGluR2 subunit has been shown to be required for long-term potentiation at the mossy fiber input in the hippocampus (Yokoi et al., 1996).
Weight
~110 - 120 kDa
Gene Id
24415
SUPPLIER INFO
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