Anti-Influenza B Virus HA monoclonal antibody (1H12)

Anti-Influenza B Virus Hemagglutinin Protein (HA) Antibody (1H12). Virions attaches to a cell by the binding of the viral surface protein hemagglutinin (HA) to sialic acid-containing receptors on the cell surface. This binding plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein is responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induce an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore. Post-translational modification HA is consists of 584 amino acids with molecular mass of 63,275. In natural infection, inactive HA is matured into HA1 and HA2. Comparing the sequence of HA1 and HA2 indicates that they are palmitoylated.