Supplier:
Aviva Systems Biology IncorporatedAnti-Glial Fibrillary Acidic Protein (GFAP)
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SPECIFICATIONS
Size
100 ul
Applications
IF, WB
Reactivities
Hum, Mouse, Rat
Format
Total IgY fraction
Presku
OAPC00115
Target
Glial Fibrillary Acidic Protein (GFAP) was discovered by Amico Bignami and co-workers as a major fibrous protein of multiple sclerosis plaques (1). It was subsequently found to be a member of the 10nm or intermediate filament (IF) family, specifically the IF family Class III, which also includes peripherin, desmin and vimentin. GFAP is strongly and specifically expressed in astrocytes and certain other astroglia in the CNS, in satellite cells, peripheral ganglia, and in non-myelinating Schwann cells in peripheral nerves. In many damage and disease states GFAP expression is heavily upregulated in astrocytes. In addition, neural stem cells frequently strongly express GFAP. Point mutations in the protein coding region of the GFAP gene lead to Alexander disease which is characterized by the presence of abnormal astrocytes containing GFAP protein aggregates known as Rosenthal fibers (2).
Weight
~50kDa
Gene Id
281189
SUPPLIER INFO
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