Supplier:
Aviva Systems Biology IncorporatedAnti- GAP-43
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SPECIFICATIONS
Size
100 ul
Applications
IF, WB
Reactivities
Hum, Mouse, Rat
Format
chicken polyclonal antibody, total IgY fraction
Presku
OAPC00136
Target
GAP-43 is thought to have an important role in development and plasticity because it is expressed at high levels in neuronal growth cones during development and during axonal regeneration (Benowitz and Routtenberg, 1997). There is also evidence from knockout animals that GAP-43 serves to amplify pathfinding signals from the growth cone (Strittmatter et al., 1995). GAP-43 is thought to mediate at least some of these effects via interaction with actin. Importantly, phosphorylation at Ser41 by protein kinase C modulates the interaction of GAP-43 with actin (He et al., 1997) and may also affect neurotransmitter release during forms of plasticity like LTP (Hulo et al., 2002).
Weight
~43kDa
Gene Id
29423
SUPPLIER INFO
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