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Anti-GABA Transporter (GAT) 3

Anti-GABA Transporter (GAT) 3

Specific for the ~67k GAT-3 protein. Immunolabeling is blocked by the peptide used as antigen. Prepared from rabbit serum by affinity purification via chromatography with a column made with the peptide used as antigen.

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SPECIFICATIONS

Size

100 ul

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Mouse, Rat

Format

Affinity purified, polyclonal antibody

Presku

OAPC00139

Target

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) subtype. GABA plasma membrane transporters (GATs) influence synaptic neurotransmission by high-affinity uptake and release of GABA. To date, four distinct GABA transporters have been identified: GAT-1, GAT-2, GAT-3, and BGT-1. GAT-3 has been found to be localized to astrocytes within the cerebral cortex indicating that this transporter mediates GABA uptake into glial cells (Minelli et al., 1996).

Weight

~67kDa

Gene Id

79213

SUPPLIER INFO

Aviva Systems Biology Incorporated

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