Anti-COBRA 1

Supplier: Aviva Systems Biology Incorporated

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Specific for the ~62k COBRA1 protein in Western blots of neonatal rat brain lysate. Protein G purified culture supernatant.

Reactivities:	Human, Mouse, Rat
Hosts:	Mouse
Applications:	Western Blot
Presku:	OAPC00093
Size:	100 ul
Weight:	~62kDa
Clone:	F7E4
Gene:	25920
Format:	Purified mouse monoclonal antibody
Target:	COBRA1 (cofactor of BRCA1) also known as NELF-B, is an essential component of the negative elongation factor (NELF) complex. COBRA1 has been shown to directly bind estrogen receptor alpha (ER alpha) and repress ER alpha -mediated transcription (Aiyar SE et al., 2004). COBRA1 has also been demonstrated to interact with c-Jun and c-Fos suggesting a role in modulation of the AP-1 pathway and therefore may be important in cell proliferation, differentiation, apoptosis and oncogeneis (Zhong H et al., 2004)
Isotype:	IgG¹