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Anti-Clavesin 1/2

Anti-Clavesin 1/2

Specific for the ~ 35 kDa clavesin 1/2 protein doublet in Western blots of rat brain lysate. Isoform-specific knock down in cultured hippocampal neurons indicates that the lower and upper bands are clavesin 1 and 2, respectively. Prepared from serum by affinity purification using a column to which the peptide antigen was coupled.

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SPECIFICATIONS

Size

100 ul

Applications

ICC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Format

Affinity purified polyclonal antibody

Presku

OAPC00092

Target

Clavesin (clathrin vesicle associated Sec14 protein) is a novel neuron specific protein that has recently been identified and shown to be required for normal morphology of late endosomes and/or lysosomes as lentiviral-mediated knockdown of clavesin in hippocampal neurons causes lysosomal defects (Katoh et al., 2009). Additionally, upregulation of clavesin in human hepatocellular carcinoma has recently been demonstrated thus making it a useful marker for this disease state (Zhao et al., 2008).

Weight

~35kDa

Gene Id

366311

SUPPLIER INFO

Aviva Systems Biology Incorporated

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