Centrin 1 ( human; 172 aa, MW; 19,570) plays a fundamental role in microtubule-organizing center structure and function. Centrins, also known as caltractins, are a family of calcium-binding phosphoproteins found in the centrosome of eukaryotes. Centrins are present in the centrioles and pericentriolar lattice. Human centrin genes are CETN1, CETN2 and CETN3. Centrins are required for duplication of centrioles. They may also play a role in severing of microtubules by causing calcium-mediated contraction. Applications: WB, IF