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Anti-Calcitonin Gene Related Peptide (CGRP)

Anti-Calcitonin Gene Related Peptide (CGRP)

Supplier: Aviva Systems Biology Incorporated
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Specific for Calcitonin Gene Related Peptide. Also recognizes rat beta-CGRP and human alpha-CGRP (10-fold less sensitivity compared to rat alpha-CGRP). Suggested positive controls are dorsal root ganglia, pancreas and gut. Protein G purified
Reactivities: Human, Rat
Hosts: Mouse
Applications: Immunocytochemistry
Presku: OAPC00089
Size: 100 ul
Gene: 24241
Format: affinity purified monoclonal antibody
Target: Calcitonin Gene Related Peptide [CGRP] is a 37 amino acid peptide and is the most potent endogenous vasodilator currently known (Brain et al.,1985). CGRP is primarily produced in nervous tissue, however, its receptors are expressed throughout the body. CGRP is also strongly implicated in the vasodilatory effect of endogenous cannabinoid anandamide in the brain. This effect was found to be antagonized by capsazepine. CGRP is also currently a major target of research in regards to factors effecting the onset of migraine headaches (Edvinsson L., 2003). CGRP antibodies have been used successfully in immunoneutralization (Wong et al., 1993)
Isotype: IgG2a
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