Anti-Beta III Tubulin

Supplier: Aviva Systems Biology Incorporated

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Specific for the ~55kDa beta III tubulin protein. This clone is similar to the monoclonal antibody Tuj1. Protein G purified culture supernatant.

Hosts:	Mouse
Applications:	Immunohistochemistry, Western Blot
Presku:	OAPC00075
Size:	100 ul
Weight:	~55kDa
Clone:	AA10
Gene:	246118
Format:	Affinity purified, monoclonal antibody
Target:	Tubulin is the major constituent of microtubules, existing as a heterodimer of the alpha and beta subunits. The beta III isoform of tubulin is found almost exclusively in neuronal processes of adult tissues and is therefore an excellent marker for neurons. Neuron specific, posttranslational modifications within the C-terminal domain of beta III tubulin have been shown to be developmentally regulated suggesting that they may serve to modulate the interaction of tubulin with microtubule associated proteins (Lee et al., 1990). Additionally, beta III tubulin has been found to be highly expressed in cancer cells such as small cell lung cancer, large cell neuroendocrine carcinoma and adenocarcinomas and is correlated with an increasing histological degree of malignancy (Katsetos et al., 2003)
Isotype:	IgG