Supplier:
Aviva Systems Biology IncorporatedAnti-Beta III Tubulin
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SPECIFICATIONS
Size
100 ul
Applications
IHC, WB
Hosts
Mouse
Clone
AA10
Format
Affinity purified, monoclonal antibody
Presku
OAPC00075
Target
Tubulin is the major constituent of microtubules, existing as a heterodimer of the alpha and beta subunits. The beta III isoform of tubulin is found almost exclusively in neuronal processes of adult tissues and is therefore an excellent marker for neurons. Neuron specific, posttranslational modifications within the C-terminal domain of beta III tubulin have been shown to be developmentally regulated suggesting that they may serve to modulate the interaction of tubulin with microtubule associated proteins (Lee et al., 1990). Additionally, beta III tubulin has been found to be highly expressed in cancer cells such as small cell lung cancer, large cell neuroendocrine carcinoma and adenocarcinomas and is correlated with an increasing histological degree of malignancy (Katsetos et al., 2003)
Weight
~55kDa
Gene Id
246118
Isotype
IgG
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