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Anti-Amyloid Precursor Protein

Anti-Amyloid Precursor Protein

Specific for ~115k APP protein. Immunolabeling of the APP protein band is completely blocked by preadsorption of the antibody with the peptide used as antigen. Prepared from rabbit serum by affinity purification on a column made with the C-terminal peptide used as antigen.

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SPECIFICATIONS

Size

100 ul

Applications

WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat, Can

Format

Affinity purified, polyclonal antibody

Presku

OAPC00023

Target

A large body of evidence has implicated the amyloid precursor protein (APP) in the pathogenesis of Alzheimer's disease (AD) (Kamenetz et al., 2003). The phosphorylation of APP at Thr668 is thought to play a critical role in generation of the soluble APP (beta) and beta-amyloid peptide (abeta) which are the major components of senile plaques in patient brains inflicted with AD (Liu et al., 2003; Ando et al., 2001).

Weight

~115kDa

Gene Id

54226

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