Anti-Alpha II Spectrin

Supplier: Aviva Systems Biology Incorporated

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Specific for the ~240 k alpha II spectrin protein. neat serum

Reactivities:	Human, Mouse, Rat
Hosts:	Rabbit
Applications:	Immunofluorescence, Western Blot
Presku:	OAPC00144
Size:	100 ul
Weight:	~240kDa
Format:	polyclonal antibody
Target:	The spectrin family of cytoskeletal proteins is comprised of 2 alpha genes (alpha 1 and alpha 2) and five beta genes (beta 1- beta 5). Spectrins have been shown to function as scaffolding proteins in mechanical support of the plasma membrane as well as bind other membrane proteins and lipids (Bennett and Baines 2001). Defects in spectrin genes have been linked to some forms of hereditary spherocytosis, a type of auto-hemolytic anemia which is characterized by spherical red blood cells that are more prone to lysis (Eber and Lux 2004).