Anne, Xenopus/Amphibian,ins are a multigene family of Ca++-regulated phospholipid-binding proteins. They serve as membrane-membrane, or membrane-cytoskeleton linkers, and regulate the formation of lipid domains in the plasma membrane. Anne, Xenopus/Amphibian,ins possess a series of unique 70 amino acid anne, Xenopus/Amphibian,in-repeat modules that form a curved disk and allow for the creation of an intercessory comple, Xenopus/Amphibian, between plasma membrane and cytofilaments. Anne, Xenopus/Amphibian,in II is a heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of AN, Xenopus/Amphibian,A2/p36. Anne, Xenopus/Amphibian,in II interacts with ATP1B1 and DYSF. Anne, Xenopus/Amphibian,in II also interacts with human cytomegalovirus (HCMV).