Alexa Fluor(R) 647 anti-human LAP (TGF-beta1)

TGF-beta1 (transforming growth factor beta1) is a multifunctional cytokine which regulates cellular proliferation and differentiation. It is ubiquitously expressed by many kinds of cells. Platelets express high level of TGF-beta. TGF-beta is synthesized as a large protein precursor and then secreted as a complex of TGF-beta and LAP (latency-associated peptide). TGF-beta requires activation before it binds to its receptors and exerts functions. It has been reported that LAP-TGF-beta binds to the integrins alphavbeta1, alphavbeta6, alphavbeta8 and alpha8beta1 through RGD domain. TGF-beta plays important roles in control proliferation and differentiation of epithelial cells, endothelial cells, fibroblasts, neurons, osteoclasts, and osteoblasts. TGF-beta is believed to be important in regulation of the development of Treg, Th17, and Th9 cells. Recent study has shown that LAP is an activated Treg surface marker.

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SPECIFICATIONS

Catalog Number

341801

Size

25 tests

Applications

FC

Hosts

Mouse

Reactivities

Hum

Clone

BG/hLAP

Gene Id

7040

Isotype

Mouse IgG1

Clonality

Monoclonal

Dilutions

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is 5 microl per million cells or 5 microl per 100 microl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.* Alexa Fluor(R) 647 has a maximum emission of 668 nm when it is excited at 633nm / 635nm.** Alexa Fluor(R) is a registered trademark of Molecular Probes, Inc. Alexa Fluor(R) dye antibody conjugates are sold under license from Molecular Probes, Inc. for research use only, except for use in combination with microarrays and high content screening, and are covered by pending and issued patents.

Storage Temp

4 C

Concentration

Shipping Temp

Ambient RT

Storage Buffer

The antibody solution should be stored undiluted at 4C and protected from prolonged exposure to light. Do not freeze.

Alternative Names

TGFB, TGFB1, DPD1, Latency Associated Peptide (LAP), TGF-beta, TGF-B1

Regulatory Status

RUO