Alexa Fluor(R) 647 anti-human CD191 (CCR1)

CCR1 is a chemokine receptor that binds to multiple proinflammatory chemokines. CCR1 is expressed by monocytes/macrophages (≈87% of the peripheral blood), natural killer cells, T cells, DC, monocytes, basophils, eosinophils, osteoclasts, platelets, bone marrow stromal cells, human airway smooth muscle cells (ASMC), and increases in allograft recipients in peripheral blood before rejection (1-3). CCR1 plays a key role in T cell-mediated liver diseases, animal models of pulmonary fibrosis, and might be involved in asthma (1, 4). In addition, CCR1 and CCL23 promoted the chemotactic migration and differentiation of endothelial cells, and neovascularization in the chick chorioallantoic membrane (5).